4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

Base Information

Chemical Name:4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide
CAS No.:903876-81-3
Molecular Formula:C₃₀H₂₈F₃N₅O₄S
Molecular Weight:611.645
Hs Code.:

4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-<i>d</i>]pyridazin-6-yl]-biphenyl-2-sulfonic acid <i>tert</i>-butylamide

Synonyms:4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

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Chemical Property of 4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

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Technology Process of 4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

There total 4 articles about 4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 280119-94-0
1-[4-methoxyphenyl]-3-trifluoromethyl-4-methyl-6-[4-bromophenyl]-1,6-dihydropyrazolo-[3,4-d]-pyridazin-7-one

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 903876-81-3
4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In benzene; at 80 ℃;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: (Z)-2,2,2-trifluoro-N'-(4-methoxyphenyl)acetohydrazonoyl bromide

: 903876-81-3
4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

Guidance literature:: Multi-step reaction with 3 steps

1: NaOEt / ethanol

2: 80 percent / ethanol / Heating

3: 80 percent / Pd(Ph₃P)4; aq. Na₂CO₃ / benzene / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium ethanolate; sodium carbonate; In ethanol; benzene; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: 280119-93-9
ethyl 1-[4-methoxyphenyl]-3-trifluoromethyl-4-acetylpyrazole-5-carboxylate

: 903876-81-3
4'-[1-(4-methoxy-phenyl)-4-methyl-7-oxo-3-trifluoromethyl-1,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / ethanol / Heating

2: 80 percent / Pd(Ph₃P)4; aq. Na₂CO₃ / benzene / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; benzene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.04.044