4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

Base Information

Chemical Name:4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde
CAS No.:865138-10-9
Molecular Formula:C₂₆H₂₁F₃N₂O
Molecular Weight:434.461
Hs Code.:

Synonyms:4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

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Chemical Property of 4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

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Technology Process of 4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

There total 5 articles about 4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 865137-86-6
[4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)phenyl]methanol

: 865138-10-9
4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

Guidance literature:: With manganese(IV) oxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 459820-10-1
3-[4-(Trifluoromethyl)phenyl]-1H-pyrazole-5-carbaldehyde

: 865138-10-9
4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2 h / 20 °C

3: potassium carbonate / dnf / 1 h / 120 °C

4: manganese(IV) oxide / tetrahydrofuran / 2 h / 20 °C

With manganese(IV) oxide; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; dnf; ethanol; N,N-dimethyl-formamide;

Reference yield:

: C₁₈H₁₃F₃N₂

: 865138-10-9
4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2 h / 20 °C

2: potassium carbonate / dnf / 1 h / 120 °C

3: manganese(IV) oxide / tetrahydrofuran / 2 h / 20 °C

With manganese(IV) oxide; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; dnf; ethanol;