2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide

Base Information

Chemical Name:2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide
CAS No.:855316-57-3
Molecular Formula:C₂₉H₃₃F₂NO₅
Molecular Weight:513.582
Hs Code.:

Synonyms:2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide

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Chemical Property of 2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide

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Technology Process of 2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide

There total 6 articles about 2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 440370-41-2
4-(R)-(3,4-difluorophenyl)-4-{N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylcarbamoyl}-3-(R)-(4-methoxyphenoxymethyl)butyric acid methyl ester

: 855316-57-3
2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -30 ℃; for 2h;
DOI:10.1021/jo0504161

Reference yield:

: 96821-35-1
(E)-4-(4-methoxy-phenoxy)-but-2-enoic acid methyl ester

: 855316-57-3
2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMEDA; LiHMDS / tetrahydrofuran / 3 h / 0 °C

1.2: 56 percent / tetrahydrofuran / 3 h / -64 °C

2.1: LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1.2: Michael addition;
DOI:10.1021/jo0504161

Reference yield:

: 150-76-5
4-methoxy-phenol

: 855316-57-3
2-(R)-(3,4-difluorophenyl)-5-hydroxy-3-(R)-(4-methoxyphenoxymethyl)pentanoic acid N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 69 percent / potassium carbonate / H₂O; acetone / 18.5 h / 19 °C

2.1: TMEDA; LiHMDS / tetrahydrofuran / 3 h / 0 °C

2.2: 56 percent / tetrahydrofuran / 3 h / -64 °C

3.1: LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water; acetone; 2.2: Michael addition;
DOI:10.1021/jo0504161