(S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

Base Information

• Chemical Name: (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate
• CAS No.: 1196793-29-9
• Molecular Formula: C₃₁H₄₇ClN₈O₆
• Molecular Weight: 663.217
• Mol file: 1196793-29-9.mol

Synonyms:(S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

Chemical Property of (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate

There total 6 articles about (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{[(Z)-tert-butoxycarbonylimino]-pyrazol-1-yl-methyl}-[3-(4-methoxy-phenyl)-propyl]-carbamic acid tert-butyl ester + 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid ((S)-2-aminopentyl)-amide hydrochloride (1201179-45-4) → (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate (1196793-29-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

((S)-1-aminomethyl-butyl)-carbamic acid tert-butyl ester (1196038-51-3) → (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate (1196793-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

((S)-1-{[(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-amino]-methyl}-butyl)-carbamic acid tert-butyl ester (1196038-52-4) → (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate (1196793-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid ((S)-2-aminopentyl)-amide hydrochloride

((S)-1-aminomethyl-butyl)-carbamic acid tert-butyl ester

[(S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester

((S)-1-{[(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-amino]-methyl}-butyl)-carbamic acid tert-butyl ester

Downstream raw materials:

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid ((S)-2-{N'-[3-(4-methoxy-phenyl)-propyl]-guanidino}-pentyl)-amide