dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate

Base Information

• Chemical Name: dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate
• CAS No.: 935548-52-0
• Molecular Formula: C₃₆H₅₆F₃N₂O₇P
• Molecular Weight: 716.819
• Mol file: 935548-52-0.mol

Synonyms:dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate

Chemical Property of dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate

There total 1 articles about dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-dimethyl 2-oxo-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate (935548-32-6) → dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate (935548-51-9) + dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate (935548-52-0)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; In tetrahydrofuran; ethanol; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.09.030

Reference yield: 27.0%

dimethyl (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate (935548-52-0) → (3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonic acid (935548-86-0)

Guidance literature:

With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.09.030

upstream raw materials:

(S)-dimethyl 2-oxo-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonate

Downstream raw materials:

(3S)-2-hydroxy-3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)butylphosphonic acid