(S)-(-)-2-(FLUORODIPHENYLMETHYL)PYRROLI&

Base Information

• Chemical Name: (S)-(-)-2-(FLUORODIPHENYLMETHYL)PYRROLI&
• CAS No.: 274674-23-6
• Molecular Formula: C17H18 F N
• Molecular Weight: 255.335
• Hs Code.: 2933998090
• Mol file: 274674-23-6.mol

Synonyms:(S)-(-)-2-(FLUORODIPHENYLMETHYL)PYRROLI&;)-2-(Fluorodiphenylmethyl)pyrrolidine;(S)-(-)-2-(FLUORODIPHENYLMETHYL) PYRROLIDINE, 97% (98% EE/HPLC)

Chemical Property of (S)-(-)-2-(FLUORODIPHENYLMETHYL)PYRROLI&

Chemical Property:

• Refractive Index: n20/D 1.576(lit.)
• Boiling Point: 366.7°Cat760mmHg
• PKA: 9.38±0.10(Predicted)
• Flash Point: 175.6°C
• PSA: 12.03000
• Density: 1.098g/cm³
• LogP: 3.98050

Purity/Quality:

97% ^*data from raw suppliers

(S)-(-)-2-(Fluorodiphenylmethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of (S)-(-)-2-(FLUORODIPHENYLMETHYL)PYRROLI&

There total 3 articles about (S)-(-)-2-(FLUORODIPHENYLMETHYL)PYRROLI& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

7,7-diphenyl-4,5,6,6a-tetrahydro-1H,3H-pyrrolo<1,2-c>oxazol-2-one (160424-29-3) → (S)-2-(fluorodiphenylmethyl)pyrrolidine (274674-23-6)

Guidance literature:

With pyridine hydrogenfluoride; at 0 - 20 ℃; for 24h;

DOI:10.1021/jo048378t

Reference yield: 54.0%

(S)-diphenylprolinol (22348-32-9,63401-04-7,112022-88-5,112068-01-6) → (S)-2-(fluorodiphenylmethyl)pyrrolidine (274674-23-6)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 6.5h; Inert atmosphere;

DOI:10.1055/s-0029-1218636

Reference yield:

(S)-proline-N-ethyl carbamate methyl ester (77581-28-3,93423-88-2) → (S)-2-(fluorodiphenylmethyl)pyrrolidine (274674-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / tetrahydrofuran / 0 - 65 °C

2: 82 percent / HF*pyridine / 24 h / 0 - 20 °C

With pyridine hydrogenfluoride; In tetrahydrofuran;

DOI:10.1021/jo048378t

upstream raw materials:

7,7-diphenyl-4,5,6,6a-tetrahydro-1H,3H-pyrrolo<1,2-c>oxazol-2-one

(S)-proline-N-ethyl carbamate methyl ester

(S)-diphenylprolinol

Downstream raw materials:

C₁₉H₂₀FNO

C₂₂H₂₁FN₂

(S)-4-(2-(fluorodiphenylmethyl)pyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Refernces

• 1、 Ho, Chun-Yu,Chen, Ying-Chun,Wong, Man-Kin,Yang, Dan. "Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone". . p. 898 - 906. Retrieved 2007/10/03.
• 2、 O'Hagan, David,Royer, Frederique,Tavasli, Mustafa. "A synthesis of (S)-α-(fluorodiphenylmethyl)alkylamines by HF-pyridine treatment of 4-alkyl-5,5-diphenyl-oxazolidinones". . p. 2033 - 2036. Retrieved 2007/10/03.