Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

Base Information

Chemical Name:Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester
CAS No.:877833-47-1
Molecular Formula:C₂₆H₃₅BrO₄Si
Molecular Weight:519.551
Hs Code.:

Synonyms:Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

Suppliers and Price of Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

There total 7 articles about Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877833-42-6
4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-but-2-enal

: 877833-47-1
Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuBOTf; Et₃N / CH₂Cl₂ / 0.83 h / -55 - 0 °C

1.2: 90 percent / CH₂Cl₂ / 4 h / -70 °C

2.1: 88 percent / NaBH₄ / tetrahydrofuran; H₂O / 3.5 h / 20 °C

3.1: 80 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 12 h

4.1: 85 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 °C

5.1: 88 percent / pyridinium p-toluenesulfonate / ethanol / 72 h / 20 °C

With dmap; sodium tetrahydroborate; n-BuBOTf; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2005.11.156

Reference yield:

: 877833-53-9
4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-but-2-en-1-ol

: 877833-47-1
Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 96 percent / tetrapropylammonium perruthenate; 4-methyl-morpholine-N-oxide / CH₂Cl₂ / 2 h / 0 °C

2.1: n-BuBOTf; Et₃N / CH₂Cl₂ / 0.83 h / -55 - 0 °C

2.2: 90 percent / CH₂Cl₂ / 4 h / -70 °C

3.1: 88 percent / NaBH₄ / tetrahydrofuran; H₂O / 3.5 h / 20 °C

4.1: 80 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 12 h

5.1: 85 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 °C

6.1: 88 percent / pyridinium p-toluenesulfonate / ethanol / 72 h / 20 °C

With dmap; sodium tetrahydroborate; tetrapropylammonium perruthennate; n-BuBOTf; pyridinium p-toluenesulfonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2005.11.156

Reference yield:

: 877833-44-8
(Z)-(2R,3R)-6-(tert-Butyl-diphenyl-silanyloxy)-2,5-dimethyl-hex-4-ene-1,3-diol

: 877833-47-1
Bromo-acetic acid (Z)-(R)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-1-methyl-ethyl)-3-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 12 h

2: 85 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 °C

3: 88 percent / pyridinium p-toluenesulfonate / ethanol / 72 h / 20 °C

With dmap; pyridinium p-toluenesulfonate; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2005.11.156