3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

Base Information

Chemical Name:3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester
CAS No.:1393603-35-4
Molecular Formula:C₁₆H₂₃IO₄Si
Molecular Weight:434.346
Hs Code.:

Synonyms:3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

Suppliers and Price of 3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

There total 4 articles about 3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 121169-17-3
3-iodo-4-(methoxymethoxy)benzaldehyde

: 394657-61-5
(diphenoxy-phosphoryl)acetic acid 2-trimethylsilanyl-ethyl ester

: 1393603-35-4
3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

Guidance literature:: (diphenoxy-phosphoryl)acetic acid 2-trimethylsilanyl-ethyl ester; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.166667h; Inert atmosphere;

3-iodo-4-(methoxymethoxy)benzaldehyde; In tetrahydrofuran; toluene; at -78 - 0 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1039/c2ob25880c

Reference yield:

: 60032-63-5
4-hydroxy-3-iodo-benzaldehyde

: 1393603-35-4
3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Cooling with ice

2.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.17 h / -78 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

With 18-crown-6 ether; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1039/c2ob25880c

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 1393603-35-4
3-(3-iodo-4-methoxymethoxy-phenyl)-Z-acrylic acid 2-trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2.67 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 16.25 h / 0 - 20 °C

3.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.17 h / -78 °C / Inert atmosphere

3.2: -78 - 0 °C / Inert atmosphere

With 18-crown-6 ether; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1039/c2ob25880c