3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.1^5,9>octadeca-1(17),5(18),6,8,13,15-hexaene

Base Information

• Chemical Name: 3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.1^5,9>octadeca-1(17),5(18),6,8,13,15-hexaene
• CAS No.: 98572-18-0
• Molecular Formula: C₂₈H₂₈N₄O₄S₂
• Molecular Weight: 548.687
• Mol file: 98572-18-0.mol

Synonyms:3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.1^5,9>octadeca-1(17),5(18),6,8,13,15-hexaene

Chemical Property of 3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.1^5,9>octadeca-1(17),5(18),6,8,13,15-hexaene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.1^5,9>octadeca-1(17),5(18),6,8,13,15-hexaene

There total 18 articles about 3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.1^5,9>octadeca-1(17),5(18),6,8,13,15-hexaene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2,6-bis(chloromethyl)pyridine (3099-28-3) + sodium p-toluenesulfonamide (18522-92-4) → 3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.15,9>octadeca-1(17),5(18),6,8,13,15-hexaene (98572-18-0)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 5h;

Reference yield: 63.0%

2,6-bis[(tosyloxy)methyl]pyridine (112633-26-8) + 2,6-bis<(p-tosylamino)methyl>pyridine (112633-27-9) → 3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.15,9>octadeca-1(17),5(18),6,8,13,15-hexaene (98572-18-0)

Guidance literature:

2,6-bis<(p-tosylamino)methyl>pyridine; With sodium; In ethanol; for 1h; Inert atmosphere; Reflux;

2,6-bis[(tosyloxy)methyl]pyridine; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;

DOI:10.1039/c7ob02508d

Reference yield: 46.7%

3,11,17,18-tetraazatricyclo<11.3.1.15,9>octadeca-1(17),5(18),6,8,13,15-hexaene (115078-43-8) + p-toluenesulfonyl chloride (98-59-9) → N-(tosyl)-2,11-diaza[3,3](2,6)pyridinophane + 3,11-ditosyl-3,11,17,18-tetraazatricyclo<11.3.15,9>octadeca-1(17),5(18),6,8,13,15-hexaene (98572-18-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.inorgchem.0c01763

upstream raw materials:

2,6-bis(chloromethyl)pyridine

sodium p-toluenesulfonamide

2,6-bis-(bromomethyl)pyridine

2,6-bis<(p-tosylamino)methyl>pyridine