2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride

Base Information

Chemical Name:2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride
CAS No.:36376-47-3
Molecular Formula:C₆H₁₁N₃*2ClH
Molecular Weight:198.095
Hs Code.:2933290090
ChEMBL ID:CHEMBL3272580
Mol file:36376-47-3.mol

Synonyms:2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride;84103-51-5;4-Methylhistamine DiHCl;2-(5-methyl-1H-imidazol-4-yl)ethanamine;hydrochloride;CHEMBL3272580;HY-W580721A;AKOS026743958;PD166164;CS-0882165;EN300-85537;Z1682072469;2-(5-methyl-1H-imidazol-4-yl)ethan-1-aminehydrochloride

Suppliers and Price of 2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
4-Methyl histamine dihydrochloride
25mg
$ 355.00

Usbiological
4-Methylhistamine dihydrochloride
10mg
$ 466.00

TRC
4-MethylHistamineDihydrochloride
500mg
$ 1110.00

Tocris
4-Methylhistaminedihydrochloride
10
$ 216.00

Tocris
4-Methylhistaminedihydrochloride
50
$ 908.00

Medical Isotopes, Inc.
4-MethylHistamineDiHCl
500 mg
$ 2120.00

Matrix Scientific
2-(4-Methyl-1H-imidazol-5-yl)ethanaminedihydrochloride 95%
1g
$ 850.00

Matrix Scientific
2-(4-Methyl-1H-imidazol-5-yl)ethanaminedihydrochloride 95%
250mg
$ 350.00

Crysdot
2-(4-Methyl-1H-imidazol-5-yl)ethanaminedihydrochloride 95+%
250mg
$ 272.00

Crysdot
2-(4-Methyl-1H-imidazol-5-yl)ethanaminedihydrochloride 95+%
1g
$ 680.00

Total 18 raw suppliers

Chemical Property of 2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride

Chemical Property:

Vapor Pressure:6.34E-05mmHg at 25°C
Melting Point:231-233℃ (ethanol )
Boiling Point:345°Cat760mmHg
Flash Point:189.3°C
PSA：54.70000
Density:1.1g/cm³
LogP:2.52360
Storage Temp.:Desiccate at RT
Solubility.:DMSO (Slightly, Heated), Methanol (Slightly)
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:161.0719751
Heavy Atom Count:10
Complexity:84.4

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl histamine dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(N=CN1)CCN.Cl
Description 4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.
Uses Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells.

Technology Process of 2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride

There total 5 articles about 2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 120231-08-5
2-<5-methyl-1-(phenylmethyl)-1H-imidazol-4-yl>ethanamine

: 36376-47-3
2-<5-methyl-1H-imidazol-4-yl>ethanamine dihydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; for 20h; under 2585.7 Torr;
DOI:10.1021/jo00274a048

Reference yield:

: 75815-57-5
5-methyl-1-(phenylmethyl)-1H-imidazole-4-carboxaldehyde

: 36376-47-3
2-<5-methyl-1H-imidazol-4-yl>ethanamine dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / ammonium acetate / 5 h / 40 - 45 °C

2: 74 percent / sodium hypophosphite hydrate / 10percent Pd/C / tetrahydrofuran; H₂O / 1 h / Ambient temperature

3: lithium aluminum hydride (LAH) / tetrahydrofuran / 3 h / Ambient temperature

4: 85 percent / H₂ / 10percent Pd/C / ethanol / 20 h / 50 °C / 2585.7 Torr

With ammonium acetate; lithium aluminium tetrahydride; sodium hypophosphite; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jo00274a048

Reference yield:

: 75815-55-3
5-methyl-1-(phenylmethyl)-1H-imidazole-4-methanol

: 36376-47-3
2-<5-methyl-1H-imidazol-4-yl>ethanamine dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / activ. MnO₂ / CH₂Cl₂ / 18 h / Ambient temperature

2: 82 percent / ammonium acetate / 5 h / 40 - 45 °C

3: 74 percent / sodium hypophosphite hydrate / 10percent Pd/C / tetrahydrofuran; H₂O / 1 h / Ambient temperature

4: lithium aluminum hydride (LAH) / tetrahydrofuran / 3 h / Ambient temperature

5: 85 percent / H₂ / 10percent Pd/C / ethanol / 20 h / 50 °C / 2585.7 Torr

With ammonium acetate; manganese(IV) oxide; lithium aluminium tetrahydride; sodium hypophosphite; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jo00274a048