Technology Process of C34H43NO5Si
There total 1 articles about C34H43NO5Si which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-4-benzyl-3-propionyl-2-oxazolidinone;
With
di-n-butylboryl trifluoromethanesulfonate; triethylamine;
In
dichloromethane;
at 0 ℃;
for 1h;
(2S, 3S)-5-(tert-butyldiphenylsilyloxy)-3-methylpentane-1,2-diol;
In
dichloromethane;
at -78 - 0 ℃;
for 1.5h;
optical yield given as %de;
DOI:10.1021/ja305864z
- Guidance literature:
-
With
sodium tetrahydroborate;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 5h;
DOI:10.1021/ja305864z
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / tetrahydrofuran; water / 5 h / 0 - 20 °C
2.1: pyridinium p-toluenesulfonate / dichloromethane / 2 h / 20 °C
3.1: diisobutylaluminium hydride / hexane; dichloromethane / 2.5 h / -78 - -40 °C / Inert atmosphere
4.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
5.1: tert.-butyl lithium; 9-methoxy-9-BBN / diethyl ether; hexane; pentane / 1.08 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / 50 °C / Inert atmosphere
6.1: Allyl ether; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 0 - 20 °C / pH 7 / aq. phosphate buffer
7.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; Allyl ether; iodine; tert.-butyl lithium; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 9-methoxy-9-BBN; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetonitrile; pentane;
5.1: Suzuki-Miyaura coupling / 5.2: Suzuki-Miyaura coupling;
DOI:10.1021/ja305864z
