3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide

Base Information

Chemical Name:3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide
CAS No.:952521-84-5
Molecular Formula:C₁₇H₁₆N₄O₃S
Molecular Weight:356.405
Hs Code.:

Synonyms:3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide

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Chemical Property of 3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide

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Technology Process of 3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide

There total 5 articles about 3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 952521-83-4
4-amino-3-(tetrahydrofuran-3-yloxy)-benzamide

: 16269-66-2
4-chlorothieno[3,2-d]pyrimidine

: 952521-84-5
3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide

Guidance literature:: In isopropyl alcohol; at 120 ℃; for 18h;

Reference yield:

: 3556-52-3
3-fluoro-4-nitro-benzamide

: 952521-84-5
3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 3.5 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C

3.1: isopropyl alcohol / 18 h / 120 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; isopropyl alcohol;

Reference yield:

: 403-21-4
3-fluoro-4-nitrobenzoic acid

: 952521-84-5
3-(tetrahydrofuran-3-yloxy)-4-(thieno[3,2-d]pyrimidin-4-ylamino)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / tetrahydrofuran / 3.5 h / 0 - 20 °C

2.1: ammonia / dichloromethane; water / 0.25 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 3.5 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 20 °C

5.1: isopropyl alcohol / 18 h / 120 °C

With thionyl chloride; ammonia; hydrogen; sodium hydride; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; isopropyl alcohol;