3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione

Base Information

Chemical Name:3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione
CAS No.:1026294-20-1
Molecular Formula:C₃₃H₃₁N₃O₅
Molecular Weight:549.626
Hs Code.:

Synonyms:3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione

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Chemical Property of 3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione

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Technology Process of 3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione

There total 7 articles about 3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 879-37-8
3-indolylacetamide

: 336883-73-9
methyl 2-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-2-oxoacetate

: 1026294-20-1
3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione

Guidance literature:: 3-indolylacetamide; methyl 2-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-2-oxoacetate; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; Further stages.;
DOI:10.1021/jo001605g

Reference yield:

: 120-72-9
indole

: 1026294-20-1
3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: 96 percent / dimethylformamide / 16 h / 20 °C

2.1: 91 percent / 1 N HCl / tetrahydrofuran / 20 °C

3.1: 82 percent / Bu₂SnO; CsF / dimethylformamide / 4 h / 20 °C

4.1: NaH / tetrahydrofuran / 1 h / 45 °C

4.2: 58 percent / tetrahydrofuran / 18 h / 45 °C

5.1: 97 percent / LiBH₄ / tetrahydrofuran; ethanol / 0 - 20 °C

6.1: diethyl ether / 0.5 h / 0 °C

6.2: 91 percent / diethyl ether; methanol / -60 - 20 °C

7.1: t-BuOK / tetrahydrofuran / 6 h / 20 °C

7.2: 74 percent / conc. HCl / tetrahydrofuran / 20 °C

With hydrogenchloride; lithium borohydride; potassium tert-butylate; sodium hydride; di(n-butyl)tin oxide; cesium fluoride; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo001605g

Reference yield:

: 336883-69-3
4-indolylbutane-1,2-diol

: 1026294-20-1
3-{1-[3-(2-hydroxyethoxy)-4-(phenylmethoxy)butyl]indol-3-yl}-4-(indol-3-yl)-3-pyrroline-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / Bu₂SnO; CsF / dimethylformamide / 4 h / 20 °C

2.1: NaH / tetrahydrofuran / 1 h / 45 °C

2.2: 58 percent / tetrahydrofuran / 18 h / 45 °C

3.1: 97 percent / LiBH₄ / tetrahydrofuran; ethanol / 0 - 20 °C

4.1: diethyl ether / 0.5 h / 0 °C

4.2: 91 percent / diethyl ether; methanol / -60 - 20 °C

5.1: t-BuOK / tetrahydrofuran / 6 h / 20 °C

5.2: 74 percent / conc. HCl / tetrahydrofuran / 20 °C

With lithium borohydride; potassium tert-butylate; sodium hydride; di(n-butyl)tin oxide; cesium fluoride; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo001605g