2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride

Base Information

Chemical Name:2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride
CAS No.:1048330-15-9
Molecular Formula:C₂₄H₂₃ClN₂O₄*ClH
Molecular Weight:475.372
Hs Code.:

Synonyms:2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride

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Chemical Property of 2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride

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Technology Process of 2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride

There total 10 articles about 2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₁ClN₂O₆

: 1048330-15-9
2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;
DOI:10.1021/jm800222k

Reference yield:

: 603122-20-9
2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-3-pyridinylcarboxaldehyde

: 1048330-15-9
2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium chlorite; dihydrogen peroxide / water; acetonitrile / 4 h / 20 °C / pH 4 / aq. phosphate buffer

2: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; sodium chlorite; dihydrogen peroxide; In 1,4-dioxane; water; acetonitrile;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 1048330-15-9
2-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: potassium carbonate / dimethyl sulfoxide / 80 °C

6: sodium chlorite; dihydrogen peroxide / water; acetonitrile / 4 h / 20 °C / pH 4 / aq. phosphate buffer

7: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; sodium chlorite; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; boron tribromide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm800222k