tert-butyl N-[4-(piperazin-1-yl)phenyl]carbamate

Base Information

Chemical Name:tert-butyl N-[4-(piperazin-1-yl)phenyl]carbamate
CAS No.:273727-52-9
Molecular Formula:C15H23 N3 O2
Molecular Weight:277.367
Hs Code.:
DSSTox Substance ID:DTXSID20585728
Wikidata:Q82477712
Mol file:273727-52-9.mol

Synonyms:273727-52-9;tert-butyl N-[4-(piperazin-1-yl)phenyl]carbamate;1-(4-Boc-amino-phenyl)-piperazine;tert-butyl N-(4-piperazin-1-ylphenyl)carbamate;(4-piperazin-1-yl-phenyl)-carbamic acid tert-butyl ester dihydrochloride;4-(1-Piperazinyl)-N-Boc-aniline;SCHEMBL6503210;DTXSID20585728;UDZIMDHNXUCYAC-UHFFFAOYSA-N;F80171;EN300-1877927;tert-Butyl [4-(piperazin-1-yl)phenyl]carbamate;(4-Piperazin-1-yl-phenyl)-carbamic Acid Tert-Butyl Ester

Suppliers and Price of tert-butyl N-[4-(piperazin-1-yl)phenyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
1-(4-Boc-amino-phenyl)-piperazine 98%
500mg
$ 549.00

American Custom Chemicals Corporation
(4-PIPERAZIN-1-YL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER DIHYDROCHLORIDE 95.00%
5MG
$ 503.88

Acrotein
4-(1-Piperazinyl)-N-Boc-aniline 97%
5g
$ 825.00

Acrotein
4-(1-Piperazinyl)-N-Boc-aniline 97%
0.5g
$ 183.33

Total 7 raw suppliers

Chemical Property of tert-butyl N-[4-(piperazin-1-yl)phenyl]carbamate

Chemical Property:

Boiling Point:393.8±27.0 °C(Predicted)
PKA:13.63±0.70(Predicted)
PSA：53.60000
Density:1.124±0.06 g/cm3(Predicted)
LogP:4.51400
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:277.17902698
Heavy Atom Count:20
Complexity:314

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Boc-amino-phenyl)-piperazine 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=CC=C(C=C1)N2CCNCC2

Technology Process of tert-butyl N-[4-(piperazin-1-yl)phenyl]carbamate

There total 1 articles about tert-butyl N-[4-(piperazin-1-yl)phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 273727-52-9
(4-Piperazin-1-yl-phenyl)-carbamic Acid tert-butyl Ester

Guidance literature:

Reference yield: 73.0%

: 273727-52-9
(4-Piperazin-1-yl-phenyl)-carbamic Acid tert-butyl Ester

: 398457-83-5
2-[4-(4-tert-Butoxycarbonylamino-phenyl)piperazin-1-yl]-4,5-dihydroimidazo[4,5,1-ij]quinolin-6-one

Guidance literature:: With 2,3-Lutidine; cesium fluoride; In dichloromethane; water;

Reference yield:

: 273727-52-9
(4-Piperazin-1-yl-phenyl)-carbamic Acid tert-butyl Ester

: 369-34-6
3,4-difluoronitrobenzene

: C₂₁H₂₅FN₄O₄

Guidance literature:: (4-Piperazin-1-yl-phenyl)-carbamic Acid tert-butyl Ester; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

3,4-difluoronitrobenzene; In acetonitrile; Inert atmosphere; Reflux;
DOI:10.1002/cmdc.202000899