({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid

Base Information

Chemical Name:({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid
CAS No.:638215-36-8
Molecular Formula:C₂₆H₂₆F₃NO₄
Molecular Weight:473.492
Hs Code.:

Synonyms:({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid

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Chemical Property of ({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid

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Technology Process of ({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid

There total 11 articles about ({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638214-35-4
ethyl ({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetate

: 638215-36-8
({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid

Guidance literature:: ethyl ({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetate; With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 638215-36-8
({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2.1: diazene-1,2-diylbis(morpholinomethanone) / tetrahydrofuran / 0.03 - 0.05 h / 20 °C

2.2: 22 h / 20 °C

3.1: 0.03 - 0.05 h / Resolution of racemate

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

With diazene-1,2-diylbis(morpholinomethanone); sodium hydroxide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 1.1: Suzuki Coupling / 2.1: Mitsunobu reaction;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638215-36-8
({2-methyl-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: diazene-1,2-diylbis(morpholinomethanone) / tetrahydrofuran / 0.03 - 0.05 h / 20 °C

5.2: 22 h / 20 °C

6.1: 0.03 - 0.05 h / Resolution of racemate

7.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

With diazene-1,2-diylbis(morpholinomethanone); manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexanes; 1,2-dimethoxyethane; chloroform; water; 3.1: Suzuki Coupling / 5.1: Mitsunobu reaction;