4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide

Base Information

Chemical Name:4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide
CAS No.:1028745-45-0
Molecular Formula:C₁₈H₂₄Cl₂F₄N₅O₅P
Molecular Weight:568.292
Hs Code.:

Synonyms:4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide

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Chemical Property of 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide

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Technology Process of 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide

There total 8 articles about 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1028745-45-0
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide

Guidance literature:

Reference yield:

: 1028745-21-2
4-azido-3-fluorobenzyl phosphoramide mustard

: C₁₁H₁₅F₃N₂O₆

: 1028745-45-0
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide

Guidance literature:: C₁₁H₁₅F₃N₂O₆; With AlH₂LiSe; In tetrahydrofuran; at 5 ℃; for 0.583333h; Inert atmosphere;

4-azido-3-fluorobenzyl phosphoramide mustard; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.04.035

Reference yield:

: 403-21-4
3-fluoro-4-nitrobenzoic acid

: 1028745-45-0
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-3-fluorobenzylphosphoramide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

2.1: sulfuric acid; sodium nitrite / water / 0.67 h / 0 °C

2.2: 1 h / 20 °C

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 1 h / 20 °C

3.2: 2 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.33 h / -78 °C

4.2: 5 h / -78 °C

5.1: ammonia / 0.17 h

6.1: AlH₂LiSe / tetrahydrofuran / 0.58 h / 5 °C / Inert atmosphere

6.2: 24 h / 20 °C / Inert atmosphere

With n-butyllithium; sulfuric acid; AlH₂LiSe; palladium 10% on activated carbon; ammonia; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium nitrite; In tetrahydrofuran; methanol; cyclohexane; water;
DOI:10.1016/j.bmc.2016.04.035