tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate
CAS No.:1610875-73-4
Molecular Formula:C₂₃H₂₅N₃O₅
Molecular Weight:423.469
Hs Code.:

Synonyms:tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

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Technology Process of tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

There total 4 articles about tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.2%

: 1610875-72-3
tert-butyl 4-(4-amino-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 1610875-73-4
tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 77337-82-7
1-bromo-2-methoxy-4-nitrobenzene

: 1610875-73-4
tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 80 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 16 h / 25 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 25 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1610875-70-1
4-(2-methoxy-4-nitrophenyl)-1H-pyrazole

: 1610875-73-4
tert-butyl 4-(4-(2-hydroxy-2-phenylacetamido)-2-methoxyphenyl)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 16 h / 25 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 25 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;