ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

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Chemical Name:ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate
CAS No.:1376191-60-4
Molecular Formula:C₃₀H₂₉ClN₄O₄
Molecular Weight:545.038
Hs Code.:

Synonyms:ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

There total 3 articles about ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 1376191-56-8
ethyl 4-(4-chlorophenyl)-3-(3-iodophenyl)-1-methyl-1H-pyrrole-2-carboxylate

: 1376191-60-4
ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm300178u

Reference yield:

: 696-41-3
m-iodobenzaldehyde

: 1376191-60-4
ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol / Reflux; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 80 °C / Inert atmosphere

With copper(l) iodide; potassium tert-butylate; potassium carbonate; L-proline; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 1376191-60-4
ethyl 4-(4-chlorophenyl)-1-methyl-3-{3-[4-(4-nitrophenyl)piperazin-1-yl]phenyl}-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol / Reflux; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 80 °C / Inert atmosphere

With copper(l) iodide; potassium tert-butylate; potassium carbonate; L-proline; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm300178u