N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Base Information

Chemical Name:N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea
CAS No.:852661-32-6
Molecular Formula:C₂₅H₃₂FN₇O
Molecular Weight:465.574
Hs Code.:

Synonyms:N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Chemical Property of N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Technology Process of N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

There total 8 articles about N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₃N₇O

: 63416-70-6
3-(4-fluorophenyl)propanal

: 852661-32-6
N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 48h;

Reference yield:

: 852661-34-8
C₁₂H₂₂N₄O₂

: 852661-32-6
N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 3102.97 Torr

2.1: triethylamine / acetonitrile / 18 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 7 h / 20 °C

3.2: brine

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 48 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 852661-33-7
tert-butyl [(1R,2R)-2-(hydroxymethyl)cyclohexyl]carbamate

: 852661-32-6
N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl]amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 1.75 h / 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 1 h / 90 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 3102.97 Torr

4.1: triethylamine / acetonitrile / 18 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 7 h / 20 °C

5.2: brine

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 48 h / 20 °C

With pyridine; sodium azide; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;