3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine

Base Information

Chemical Name:3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine
CAS No.:309967-52-0
Molecular Formula:C₂₉H₃₈N₆O₆Si
Molecular Weight:594.743
Hs Code.:

Synonyms:3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine

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Technology Process of 3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine

There total 5 articles about 3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18395-90-9
Di-tert-butyldichlorosilane

: 309967-50-8
6-O-(2-cyanoethyl)-2-N-phenylacetylguanosine

: 309967-52-0
3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine

Guidance literature:: With silver nitrate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;
DOI:10.1021/jo991097e

Reference yield:

: N-[9-(3,4-bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-6-(2-cyano-ethoxy)-9H-purin-2-yl]-2-phenyl-acetamide

: 309967-52-0
3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine

Guidance literature:: Multi-step reaction with 2 steps

1: 4.5 g / TFA / CH₂Cl₂; methanol / 0.5 h

2: 92 percent / AgNO₃ / dimethylformamide / 0.25 h / 0 °C

With silver nitrate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Cyclization;
DOI:10.1021/jo991097e

Reference yield:

: 1053644-42-0
2,4,6-Trimethyl-benzenesulfonic acid 9-((2R,3R,4R,5R)-3,4-bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-2-phenylacetylamino-9H-purin-6-yl ester

: 309967-52-0
3',5'-O-(di-tert-butylsilanediyl)-2-N-phenylacetyl-6-O-(2-cyanoethyl)guanosine

Guidance literature:: Multi-step reaction with 3 steps

1: pyrrolidine; DBU / 0.5 h / 0 °C

2: 4.5 g / TFA / CH₂Cl₂; methanol / 0.5 h

3: 92 percent / AgNO₃ / dimethylformamide / 0.25 h / 0 °C

With pyrrolidine; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Cyclization;
DOI:10.1021/jo991097e