(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Base Information

Chemical Name:(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
CAS No.:1018814-83-9
Molecular Formula:C₃₄H₃₅N₅O₄
Molecular Weight:577.683
Hs Code.:

Synonyms:(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

There total 6 articles about (6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 100-10-7
4-dimethylamino-benzaldehyde

: 574730-02-2
(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-(R)-pyrrolidin-3-yl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

: 1018814-83-9
(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Guidance literature:: With acetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm201422e

Reference yield:

: 574730-01-1
(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-((R)-1-benzylpyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione

: 1018814-83-9
(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethanol / 0.5 h / Reflux

2: acetic acid / dichloromethane / 20 °C

With palladium on activated charcoal; hydrogen; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm201422e

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 1018814-83-9
(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-((R)-1-(4-dimethylaminobenzyl)pyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Molecular sieve

2: triethylamine / chloroform / -10 °C

3: 12 - 24 h / Heating / reflux

4: hydrogen / palladium hydroxide on carbon / ethyl acetate / 24 - 48 h / 20 °C

5: acetic acid / dichloromethane / 12 - 24 h / 20 °C

With hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium hydroxide on carbon; In dichloromethane; chloroform; ethyl acetate; 1: Pictet-Spengler Cyclisation;