(S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

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Chemical Name:(S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid
CAS No.:742062-98-2
Molecular Formula:C₄₃H₆₉N₅O₁₂
Molecular Weight:848.047
Hs Code.:

(S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

Synonyms:(S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

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Chemical Property of (S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

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Technology Process of (S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

There total 10 articles about (S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid allyl ester

: 742062-98-2
(S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9
Boc-L-aIle-OH

: 742062-98-2
(S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: PyBOP; Et₃N / CH₂Cl₂ / 0 - 20 °C

2: HCl / ethyl acetate / 20 °C

3: 97 percent / PyBOP; Et₃N / CH₂Cl₂ / 0 - 20 °C

4: 97 percent / HCl / ethyl acetate / 20 °C

5: 91 percent / Et₃N; diethylcyanophosphate / tetrahydrofuran / 0 - 20 °C

6: 97 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

7: TBAF; AcOH / tetrahydrofuran / 18 h / 0 - 20 °C

8: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 18 h / 20 °C

With morpholine; hydrogenchloride; dmap; diethyl cyanophosphonate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; triethylamine; diisopropyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 308279-67-6
(S)-3-Benzyloxy-2-((2S,3R)-2-tert-butoxycarbonylamino-3-methyl-pentanoylamino)-propionic acid allyl ester

: 742062-98-2
(S)-3-Benzyloxy-2-{(2S,3R)-2-[((S)-1-{(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-piperidine-2-carbonyl)-amino]-3-methyl-pentanoylamino}-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: HCl / ethyl acetate / 20 °C

2: 97 percent / PyBOP; Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 97 percent / HCl / ethyl acetate / 20 °C

4: 91 percent / Et₃N; diethylcyanophosphate / tetrahydrofuran / 0 - 20 °C

5: 97 percent / DMAP; CSA; diisopropylcarbodiimide / CH₂Cl₂ / 20 °C

6: TBAF; AcOH / tetrahydrofuran / 18 h / 0 - 20 °C

7: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 18 h / 20 °C

With morpholine; hydrogenchloride; dmap; diethyl cyanophosphonate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; triethylamine; diisopropyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.055