(R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide

Base Information

• Chemical Name: (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide
• CAS No.: 909779-33-5
• Molecular Formula: C₂₁H₂₆ClN₃O₂
• Molecular Weight: 387.909
• Hs Code.: 2933595960
• UNII: 1AH2JG4B9H
• Mol file: 909779-33-5.mol

Synonyms:909779-33-5;Levocetirizine amide;1AH2JG4B9H;(R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide;2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetamide;Acetamide, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-;UNII-1AH2JG4B9H;SCHEMBL3847601;2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetamide;LEVOCETIRIZINE AMIDE [USP-RS];CS-0166215;2-?[2-?[4-?[(R)?-?(4-?Chlorophenyl)?phenylmethyl]?-?1-?piperazinyl]?ethoxy]?-acetamide;(R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide (Cetirizine Impurity

Chemical Property of (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide

Chemical Property:

• Boiling Point: 539.3±50.0 °C(Predicted)
• Density: 1.210±0.06 g/cm3(Predicted)
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 387.1713548
• Heavy Atom Count: 27
• Complexity: 443

Purity/Quality:

99% ^*data from raw suppliers

2-?[2-?[4-?[(R)?-?(4-?Chlorophenyl)?phenylmethyl]?-?1-?piperazinyl]?ethoxy]?-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1CCOCC(=O)N)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
• Isomeric SMILES: C1CN(CCN1CCOCC(=O)N)[C@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl
• Uses: 2-?[2-?[4-?[(R)?-?(4-?Chlorophenyl)?phenylmethyl]?-?1-?piperazinyl]?ethoxy]?-acetamide is an intermediate for the synthesis of dextrocetirizine and levocetirizine.

Technology Process of (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide

There total 2 articles about (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid (909779-48-2) → (R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide (909779-33-5)

Guidance literature:

With sodium hydroxide; In water; toluene; at 20 ℃;

Reference yield:

2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide (83881-37-2,163837-41-0,163837-43-2) → (R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide (909779-33-5) + (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (909779-47-1)

Guidance literature:

Purification / work up; Resolution of racemate;

Reference yield:

(R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide (909779-33-5) → levocetirizine (130018-77-8)

Guidance literature:

With hydrogenchloride; In water; at 65 ℃; for 4h;

upstream raw materials:

2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide

(R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide - (S)-pyrrolidone-5-carboxylic acid

Downstream raw materials:

levocetirizine