1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

Base Information

Chemical Name:1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole
CAS No.:124401-47-4
Molecular Formula:C₂₀H₂₆FNO
Molecular Weight:315.431
Hs Code.:

Synonyms:1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

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Technology Process of 1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

There total 8 articles about 1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 124401-45-2
1-cyclohexyl-2-isopropyl-4-(4-fluorophenyl)-N-methyl-1H-pyrrole-3-carboxanilide

: 124401-47-4
1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 20h; Heating;
DOI:10.1021/jm00163a011

Reference yield: 67.0%

: 124401-47-4
1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

Guidance literature:

Reference yield:

: 134538-46-8,775-31-5
1-(4-fluorophenyl)-2-nitropropene

: 124401-47-4
1-cyclohexyl-2-isopropyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / ethanol / 12 h / Heating

2: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux

3: 67 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00163a011