C₂₁H₂₈O₄

Base Information

Chemical Name:C₂₁H₂₈O₄
CAS No.:566943-67-7
Molecular Formula:C₂₁H₂₈O₄
Molecular Weight:344.451
Hs Code.:

C<sub>21</sub>H<sub>28</sub>O<sub>4</sub>

Synonyms:C₂₁H₂₈O₄

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Chemical Property of C₂₁H₂₈O₄

Chemical Property:

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Technology Process of C₂₁H₂₈O₄

There total 19 articles about C₂₁H₂₈O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 566943-66-6
C₂₁H₃₀O₄

: 566943-67-7
C₂₁H₂₈O₄

Guidance literature:: With pyridinium chlorochromate; In dichloromethane;
DOI:10.1248/cpb.51.104

Reference yield:

: 566943-50-8
(1S,4R,5R,7R)-7-Methoxymethoxy-4-vinyl-bicyclo[3.2.1]octan-2-one

: 566943-67-7
C₂₁H₂₈O₄

Guidance literature:: Multi-step reaction with 19 steps

1: 92 percent / NaBH₄ / methanol / -78 - -30 °C

2: 80 percent / NaH; Bu₄NI / tetrahydrofuran / Heating

3: 94 percent / HCl; MeOH

4: 94 percent / pyridinium chlorochromate / CH₂Cl₂

5: NaH / tetrahydrofuran

6: t-BuOK / tetrahydrofuran

7: 77 percent / 2,3-dichloro-5,6-dicyanobenzoquinone; H₂O / CH₂Cl₂

8: 94 percent / pyridinium chlorochromate / CH₂Cl₂

9: 93 percent / methanol

10: 90 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

11: 93 percent / TMS-OTf / CH₂Cl₂ / -78 - 0 °C

12: 98 percent / LiAlH₄ / tetrahydrofuran

13: pyridinium chlorochromate / CH₂Cl₂

14: tetrahydrofuran / -78 °C

15: 93 percent / NaH / tetrahydrofuran

16: 86 percent / BuSnH; 2,2'-azobisisobutyronitrile / toluene / Heating

17: 98 percent / m-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂

18: 64 percent / diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

19: 84 percent / pyridinium chlorochromate / CH₂Cl₂

With hydrogenchloride; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyl tin hydride; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; water; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; toluene; 9: retro-Dieckmann reaction;
DOI:10.1248/cpb.51.104

Reference yield:

: 566943-51-9
(1R,2S,4R,5R,7R)-7-Methoxymethoxy-4-vinyl-bicyclo[3.2.1]octan-2-ol

: 566943-67-7
C₂₁H₂₈O₄

Guidance literature:: Multi-step reaction with 18 steps

1: 80 percent / NaH; Bu₄NI / tetrahydrofuran / Heating

2: 94 percent / HCl; MeOH

3: 94 percent / pyridinium chlorochromate / CH₂Cl₂

4: NaH / tetrahydrofuran

5: t-BuOK / tetrahydrofuran

6: 77 percent / 2,3-dichloro-5,6-dicyanobenzoquinone; H₂O / CH₂Cl₂

7: 94 percent / pyridinium chlorochromate / CH₂Cl₂

8: 93 percent / methanol

9: 90 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

10: 93 percent / TMS-OTf / CH₂Cl₂ / -78 - 0 °C

11: 98 percent / LiAlH₄ / tetrahydrofuran

12: pyridinium chlorochromate / CH₂Cl₂

13: tetrahydrofuran / -78 °C

14: 93 percent / NaH / tetrahydrofuran

15: 86 percent / BuSnH; 2,2'-azobisisobutyronitrile / toluene / Heating

16: 98 percent / m-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂

17: 64 percent / diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

18: 84 percent / pyridinium chlorochromate / CH₂Cl₂

With hydrogenchloride; methanol; lithium aluminium tetrahydride; n-butyl tin hydride; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; water; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; toluene; 8: retro-Dieckmann reaction;
DOI:10.1248/cpb.51.104