Technology Process of (6-methoxy-1,3-benzothiazol-2-yl)(3-methoxy-4-phenoxyphenyl)methanone
There total 6 articles about (6-methoxy-1,3-benzothiazol-2-yl)(3-methoxy-4-phenoxyphenyl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
copper diacetate;
In
dichloromethane;
at 20 ℃;
for 18h;
4 ? Molecular sieve;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with acetone-dry ice
1.2: 2 h / Cooling with acetone-dry ice
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 18.17 h / 0 - 60 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4.1: copper diacetate / dichloromethane / 0.08 h / Molecular sieve
4.2: 18 h / 20 °C / Inert atmosphere; Molecular sieve
With
n-butyllithium; tetrabutyl ammonium fluoride; copper diacetate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm201711b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with acetone-dry ice
2.2: 2 h / Cooling with acetone-dry ice
3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 18.17 h / 0 - 60 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
5.1: copper diacetate / dichloromethane / 0.08 h / Molecular sieve
5.2: 18 h / 20 °C / Inert atmosphere; Molecular sieve
With
1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; copper diacetate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201711b
