(1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate

Base Information

• Chemical Name: (1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate
• CAS No.: 1156540-73-6
• Molecular Formula: C₁₄H₁₃NO₄
• Molecular Weight: 259.262
• Mol file: 1156540-73-6.mol

Synonyms:(1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate

Chemical Property of (1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate

There total 2 articles about (1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + succinimidyl diazoacetate (147666-20-4) → (1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate (1156540-73-6)

Guidance literature:

With Ru-pheox; In dichloromethane; at -10 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc32706f

Reference yield: 87.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + succinimidyl diazoacetate (147666-20-4) → (1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate (1156540-73-6) + (1S,2S)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate

Guidance literature:

With trans-Ru^IICl2-(2,6-di-<<(S)-4-isopropyl>oxazol-2-yl>pyridine)-(CH2=CH2); In dichloromethane; at 25 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc32706f

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + (1R,2R)-2,5-dioxopyrrolidin-1-yl 2-phenylcyclopropanecarboxylate (1156540-73-6) → (1R,2R)-morpholino(2-phenylcyclopropyl)methanone (1156540-88-3)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h; optical yield given as %ee;

DOI:10.1021/ol9005882

upstream raw materials:

styrene

succinimidyl diazoacetate

Downstream raw materials:

(1R,2R)-morpholino(2-phenylcyclopropyl)methanone

(1R,2R)-trans-2-phenylcyclopropane-1-carboxamide

N-((1R,2R)-2-phenylcyclopropylcarbonyl)-α-D-glucosamine

(1R,2R)-N-((R)-1-hydroxy-3-methylbutan-2-yl)-2-phenylcyclopropanecarboxamide