benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

Base Information

Chemical Name:benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate
CAS No.:949495-14-1
Molecular Formula:C₁₆H₂₂N₂O₃
Molecular Weight:290.362
Hs Code.:

Synonyms:benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

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Chemical Property of benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

There total 2 articles about benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949495-13-0
benzyl (3S,4R)-3-(cyclopropylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate

: 949495-14-1
benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: benzyl (3S,4R)-3-(cyclopropylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate; With borane-THF; In tetrahydrofuran; at 20 - 46 ℃; for 8h;

With water; triethylamine; at 15 - 25 ℃; for 14h; Heating / reflux;

Reference yield:

: 949495-15-2
benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride

: 949495-14-1
benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: With sodium hydroxide; In water; at 2.7 - 10 ℃; Product distribution / selectivity;

Reference yield: 80.0%

: 949495-14-1
benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

: 1314595-20-4
benzyl (3S,4S)-3-((cyclopropylamino)methyl)-4-fluoropyrrolidine-1-carboxylate hydrochloride

Guidance literature:: benzyl (3S,4R)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate; With triethylamine pentahydrogen fluoride salt; In toluene; at -5 - 10 ℃; for 0.5h;

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In toluene; at -5 - 20 ℃;

With hydrogenchloride; In methanol; toluene; at 20 ℃; Product distribution / selectivity; Heating;