[6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine

Base Information

• Chemical Name: [6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine
• CAS No.: 697299-74-4
• Molecular Formula: C₂₄H₁₈ClFN₄O
• Molecular Weight: 432.885

Synonyms:[6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine

Chemical Property of [6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine

Chemical Property:

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Technology Process of [6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine

There total 1 articles about [6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-carbamic acid tert-butyl ester (697299-73-3) → [6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine (697299-74-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

diphenyl cyanocarbonimidate (84859-47-2) + [6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine (697299-74-4) → 1-(3-{4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]quinazolin-6-yl}prop-2-ynyl)-2-phenyl-N-cyanoisourea (697299-75-5)

Guidance literature:

With triethylamine; In isopropyl alcohol; at 20 ℃; for 15h;

Reference yield:

[6-(3-amino-prop-1-ynyl)-quinazolin-4-yl]-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine (697299-74-4) + N-cyanodiphenylcarbonimidate (79463-77-7) → 1-(3-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-2-phenyl-N-cyano-isourea (697299-75-5)

Guidance literature:

With triethylamine; In isopropyl alcohol; at 20 ℃; for 15h;

upstream raw materials:

(3-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-carbamic acid tert-butyl ester

Downstream raw materials:

1-(3-{4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]quinazolin-6-yl}prop-2-ynyl)-2-phenyl-N-cyanoisourea

1-(3-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-2-phenyl-N-cyano-isourea

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