2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine

Base Information

• Chemical Name: 2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine
• CAS No.: 541550-50-9
• Molecular Formula: C₁₉H₂₄ClN₃O₃
• Molecular Weight: 377.871
• Mol file: 541550-50-9.mol

Synonyms:2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine

Chemical Property of 2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine

There total 2 articles about 2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.4%

4-(2,6-dichloropyrimidin-4-yl)morpholine (52127-83-0) + 3-(3,4-dimethoxyphenyl)-1-iodopropane (118156-83-5) → 2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine (541550-50-9) + 4-chloro-2-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine (541550-49-6)

Guidance literature:

3-(3,4-dimethoxyphenyl)-1-iodopropane; With zinc; In tetrahydrofuran; at 20 ℃;

4-(2,6-dichloropyrimidin-4-yl)morpholine; trans-benzyl(chloro)-bis(triphenylphosphine)palladium(II); In tetrahydrofuran; at 60 ℃; for 48h;

Reference yield:

4-(2,6-dichloropyrimidin-4-yl)morpholine (52127-83-0) + C11H15IO2Zn → 2-chloro-4-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine (541550-50-9) + 4-chloro-2-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine (541550-49-6)

Guidance literature:

With trans-benzyl(chloro)-bis(triphenylphosphine)palladium(II); In tetrahydrofuran; at 60 ℃; for 48h;

upstream raw materials:

4-(2,6-dichloropyrimidin-4-yl)morpholine

3-(3,4-dimethoxyphenyl)-1-iodopropane