2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

Base Information

• Chemical Name: 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid
• CAS No.: 1453211-13-6
• Molecular Formula: C₂₃H₂₃F₂N₃O₆
• Molecular Weight: 475.449
• Mol file: 1453211-13-6.mol

Synonyms:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

Chemical Property of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

There total 5 articles about 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidine (1453211-61-4) + 2-(4-aminophenoxy)-2-methyl propionic acid (117011-70-8) → 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid (1453211-13-6)

Guidance literature:

With palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl; caesium carbonate; In tert-butyl alcohol; at 120 ℃; Inert atmosphere;

Reference yield:

(2,6-difluoro-3,5-dimethoxyphenyl)methanol (1208434-90-5) → 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid (1453211-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3: caesium carbonate; palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl / tert-butyl alcohol / 120 °C / Inert atmosphere

With palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

methyl 3,5-dimethoxybenzoate (2150-37-0) → 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid (1453211-13-6)

Guidance literature:

Multi-step reaction with 5 steps

1: Selectfluor / acetonitrile / 20 °C / Cooling with ice

2: lithium borohydride / tetrahydrofuran / 87 h / 20 °C / Cooling with ice

3: triethylamine / tetrahydrofuran / 1 h / Cooling with ice

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5: caesium carbonate; palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl / tert-butyl alcohol / 120 °C / Inert atmosphere

With lithium borohydride; palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl; potassium carbonate; caesium carbonate; Selectfluor; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

upstream raw materials:

methyl 3,5-dimethoxybenzoate

methyl 2,6-difluoro-3,5-dimethoxybenzoate

(2,6-difluoro-3,5-dimethoxyphenyl)methanol

(2,6-difluoro-3,5-dimethoxyphenyl)methyl methanesulfonate