2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

Base Information

Chemical Name:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid
CAS No.:1453211-13-6
Molecular Formula:C₂₃H₂₃F₂N₃O₆
Molecular Weight:475.449
Hs Code.:

Synonyms:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

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Chemical Property of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

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Technology Process of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

There total 5 articles about 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453211-61-4
2-chloro-5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidine

: 117011-70-8
2-(4-aminophenoxy)-2-methyl propionic acid

: 1453211-13-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

Guidance literature:: With palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl; caesium carbonate; In tert-butyl alcohol; at 120 ℃; Inert atmosphere;

Reference yield:

: 1208434-90-5
(2,6-difluoro-3,5-dimethoxyphenyl)methanol

: 1453211-13-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3: caesium carbonate; palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl / tert-butyl alcohol / 120 °C / Inert atmosphere

With palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 2150-37-0
methyl 3,5-dimethoxybenzoate

: 1453211-13-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)phenoxy]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Selectfluor / acetonitrile / 20 °C / Cooling with ice

2: lithium borohydride / tetrahydrofuran / 87 h / 20 °C / Cooling with ice

3: triethylamine / tetrahydrofuran / 1 h / Cooling with ice

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5: caesium carbonate; palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl / tert-butyl alcohol / 120 °C / Inert atmosphere

With lithium borohydride; palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl; potassium carbonate; caesium carbonate; Selectfluor; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;