4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline

Base Information

• Chemical Name: 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline
• CAS No.: 261517-65-1
• Molecular Formula: C₃₂H₃₁N₃O₇
• Molecular Weight: 569.614
• Mol file: 261517-65-1.mol

Synonyms:4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline

Chemical Property of 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline

There total 5 articles about 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2S,4R)-4-[(4-Methoxy-phenyl)-diphenyl-methoxy]-1-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-pyrrolidine-2-carboxylic acid methyl ester → 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline (261517-65-1)

Guidance literature:

With potassium hydroxide; In methanol; at 0 ℃; for 0.5h;

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) → 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline (261517-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC; pyridine / acetonitrile / 3 h

2: DIPEA / 1 h / 70 °C

3: 6.5 mmol / aq. KOH / methanol / 0.5 h / 0 °C

With pyridine; potassium hydroxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile; 1: Acylation / 2: Etherification / 3: Hydrolysis;

DOI:10.1080/07328319908044625

Reference yield:

thymidyl acetic acid (20924-05-4) → 4-O-monomethoxytrityl-N-(thymine-1-ylacetyl)-L-hydroxyproline (261517-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC; pyridine / acetonitrile / 3 h

2: DIPEA / 1 h / 70 °C

3: 6.5 mmol / aq. KOH / methanol / 0.5 h / 0 °C

With pyridine; potassium hydroxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile; 1: Acylation / 2: Etherification / 3: Hydrolysis;

DOI:10.1080/07328319908044625

upstream raw materials:

thymidyl acetic acid

L-4-hydroxyproline methyl ester hydrochloride

methyl ester of trans-4-hydroxy-L-proline hydrochloride

(R)-4-hydroxy-L-proline ethyl ester