4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide
• CAS No.: 1355019-72-5
• Molecular Formula: C₂₂H₂₀N₂O₂S
• Molecular Weight: 376.479
• Mol file: 1355019-72-5.mol

Synonyms:4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide

Chemical Property of 4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of 4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide

There total 1 articles about 4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(2-aminophenyl)-6-methylindole (1264954-25-7) + p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide (1355019-72-5)

Guidance literature:

With pyridine; Inert atmosphere; Reflux;

DOI:10.1021/ol203275b

Reference yield: 88.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + 4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide (1355019-72-5) → butyl 2-(10-methyl-5-tosyl-5,6-dihydroindolo[1,2-a]quinoxalin-6-yl)acetate (1355019-87-2)

Guidance literature:

With lithium acetate; copper diacetate; sodium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol203275b

Reference yield: 57.0%

4-methyl-N-(2-(6-methyl-1H-indol-1-yl)phenyl)benzenesulfonamide (1355019-72-5) → 3-methyl-10-tosyl-10H-benzo[4,5]imidazo[1,2-a]indole

Guidance literature:

With ferrocene; tetrabutylammonium tetrafluoroborate; In ethanol; acetonitrile; at 70 ℃; for 4h; Electrolysis;

DOI:10.1039/c8cc09899a

upstream raw materials:

N-(2-aminophenyl)-6-methylindole

p-toluenesulfonyl chloride

Downstream raw materials:

butyl 2-(10-methyl-5-tosyl-5,6-dihydroindolo[1,2-a]quinoxalin-6-yl)acetate