5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide

Base Information

Chemical Name:5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide
CAS No.:81580-21-4
Molecular Formula:C₂₀H₂₇N₃O₃
Molecular Weight:357.453
Hs Code.:

Synonyms:5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide

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Chemical Property of 5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide

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Technology Process of 5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide

There total 4 articles about 5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 30566-92-8
5-(N,N-dibenzylamino)acetylsalicylamide

: 64450-22-2
1-(Methyl-p-tolyl-amino)-propan-2-one

: 81580-21-4
5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide

Guidance literature:: With hydrogen; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00348a013

Reference yield:

: 623-08-5
N-methyl-p-toluidine

: 81580-21-4
5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaHCO₃ / ethanol / 21 h

2: 65 percent / H₂, AcOH / 10percent PdO/C, 10percent Pt/C / methanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydrogencarbonate; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol; ethanol;
DOI:10.1021/jm00348a013

Reference yield:

: 73866-23-6
5-(2-bromoacetyl)-2-hydroxybenzamide

: 81580-21-4
5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / butan-2-one / 0.67 h / Heating

2: 65 percent / H₂, AcOH / 10percent PdO/C, 10percent Pt/C / methanol / 760 Torr / Ambient temperature

With hydrogen; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol; butanone;
DOI:10.1021/jm00348a013