N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

Base Information

Chemical Name:N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide
CAS No.:1383341-50-1
Molecular Formula:C₂₁H₂₅N₅O
Molecular Weight:363.462
Hs Code.:

Synonyms:N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

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Chemical Property of N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

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Technology Process of N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

There total 6 articles about N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383342-54-8
N-{1-[5-(1-methylethyl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4-piperidinyl}benzamide

: 1383341-50-1
N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

Guidance literature:: With methanol; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1383341-50-1
N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 1 h / Cooling

2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C / microwave irradiation

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / microwave irradiation

4.1: hydrogen / palladium on activated charcoal / ethanol / 21 h

5.1: caesium carbonate; methanol / tetrahydrofuran / 4 h / 20 °C

With methanol; hydrogen; sodium hydride; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 252723-17-4
7-Benzenesulfonyl-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1383341-50-1
N-[1-(5-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C / microwave irradiation

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / microwave irradiation

3: hydrogen / palladium on activated charcoal / ethanol / 21 h

4: caesium carbonate; methanol / tetrahydrofuran / 4 h / 20 °C

With methanol; hydrogen; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water;