5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole

Base Information

• Chemical Name: 5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole
• CAS No.: 1605324-20-6
• Molecular Formula: C₁₉H₂₁N₃S
• Molecular Weight: 323.462
• Mol file: 1605324-20-6.mol

Synonyms:5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole

Chemical Property of 5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole

There total 5 articles about 5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-phenylethynyl n-butyl sulfide (127060-60-0) + benzyl azide (622-79-7) → 5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole (1605324-20-6)

Guidance literature:

With di(rhodium)tetracarbonyl dichloride; In chloroform; at 40 ℃; for 12h; regioselective reaction;

DOI:10.1002/adsc.201801216

Reference yield: 86.0%

S-butyl benzenesulfonothioate (5184-59-8) + phenylacetylene (536-74-3) + benzyl azide (622-79-7) → 5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole (1605324-20-6)

Guidance literature:

With copper(l) iodide; lithium tert-butoxide; In tetrahydrofuran; at 40 ℃; for 12h; regioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1002/anie.201509124

Reference yield: 65.0%

n-butyllithium (109-72-8,29786-93-4) + (thiocyanatoethynyl)benzene (83893-97-4) + benzyl azide (622-79-7) → 5-n-butylmercapto-(1-benzyl)-4-phenyl-1H-1,2,3-triazole (1605324-20-6)

Guidance literature:

(thiocyanatoethynyl)benzene; benzyl azide; With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In tetrahydrofuran; at 20 ℃; for 24h;

n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃; for 12h; regioselective reaction;

DOI:10.1002/adsc.201901014

upstream raw materials:

1-phenylethynyl n-butyl sulfide

benzyl azide

phenylacetylene

S-butyl benzenesulfonothioate