3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Base Information

Chemical Name:3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide
CAS No.:698355-55-4
Molecular Formula:C₂₂H₂₆N₂O₃S₃
Molecular Weight:462.658
Hs Code.:

Synonyms:3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

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Chemical Property of 3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

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Technology Process of 3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

There total 2 articles about 3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 147878-72-6
(4-bromophenyl)-thiazol-2-yl-methanone

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 698355-55-4
3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Guidance literature:: With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 2h;

Reference yield: 79.0%

: C₁₈H₂₆BNO₄S₂

: 147878-72-6
(4-bromophenyl)-thiazol-2-yl-methanone

: 698355-55-4
3-[4-(thiazole-2-carbonyl)-phenyl]-5-isobutyl-N-tert-butylthiophene-2-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In ethanol; toluene; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.03.064