2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester

Base Information

Chemical Name:2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester
CAS No.:479495-88-0
Molecular Formula:C₄₂H₅₇NO₆SSi
Molecular Weight:732.069
Hs Code.:

2-benzyl-3-({1-[1-<i>tert</i>-butoxycarbonylamino-2-(4-<i>tert</i>-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid <i>S</i>-benzyl ester

Synonyms:2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester

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Chemical Property of 2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester

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Technology Process of 2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester

There total 4 articles about 2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 75-78-5,30107-43-8
dimethylsilicon dichloride

: 479495-63-1
2-benzyl-3-hydroxy-pent-4-enethioic S-benzyl ester

: 479495-56-2
(S,S)-[1-(4-tert-butoxy-benzyl)-2-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

: 479495-88-0
2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester

Guidance literature:: With pyridine;
DOI:10.1021/ja027150p

Reference yield:

: 3-Phenyl-propionic acid (1R,2S)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl ester

: 479495-88-0
2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Cy₂BOTf; NEt₃ / CH₂Cl₂

1.2: aq. NaOH / tetrahydrofuran; methanol

2.1: 99 percent / DCC; DMAP / CH₂Cl₂

3.1: 32 percent / pyridine

With pyridine; dmap; triethylamine; dicyclohexyl-carbodiimide; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane;
DOI:10.1021/ja027150p

Reference yield:

: 74974-37-1
tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-oxoethyl]carbamate

: 479495-88-0
2-benzyl-3-({1-[1-tert-butoxycarbonylamino-2-(4-tert-butoxy-phenyl)-ethyl]-but-3-enyloxy}-dimethyl-silanyloxy)-pent-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / -78 - 0 °C

2: 32 percent / pyridine

With pyridine; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja027150p