{2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone

Base Information

Chemical Name:{2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone
CAS No.:183129-92-2
Molecular Formula:C₂₁H₂₀ClNOS
Molecular Weight:369.915
Hs Code.:

Synonyms:{2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone

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Chemical Property of {2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone

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Technology Process of {2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone

There total 5 articles about {2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-41-4,27536-89-6
ethylbenzene

: 183129-92-2
{2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / 1,2-dichloro-ethane / 4 h

2: hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 20 - 160 °C

3: NaBH₄, BF₃*OEt₂

4: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

5: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium hydroxide; sodium hypochlorite; sodium tetrahydroborate; aluminium trichloride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; sulfur; hydrazine hydrate; triethylamine; In ethylene glycol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 40018-25-5
2-Chlorobenzoyl acetonitrile

: 183129-85-3
4-(4-Ethyl-phenyl)-butyraldehyde

: 183129-92-2
{2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone

Guidance literature:: With sulfur; triethylamine; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 4h;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 5467-53-8
γ-(p-ethylphenyl)butyric acid

: 183129-92-2
{2-Amino-5-[2-(4-ethyl-phenyl)-ethyl]-thiophen-3-yl}-(2-chloro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄, BF₃*OEt₂

2: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

3: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium hydrogencarbonate; sulfur; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/0223-5234(96)85877-6