ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate

Base Information

• Chemical Name: ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate
• CAS No.: 212139-24-7
• Molecular Formula: C₂₆H₂₉N₃O₃
• Molecular Weight: 431.535
• Mol file: 212139-24-7.mol

Synonyms:ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate

Chemical Property of ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate

There total 1 articles about ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-[4-[[(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy]phenyl]-3-(7-cyano-2-naphthyl)propionic acid ethyl ester (204325-47-3) → ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate (212139-24-7)

Guidance literature:

2-[4-[[(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy]phenyl]-3-(7-cyano-2-naphthyl)propionic acid ethyl ester; With hydrogenchloride; ethanol; at 20 ℃; for 24h;

With ammonia; In ethanol; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2004.02.032

Reference yield: 59.0%

ethyl propanimidate hydrochloride (40546-35-8) + ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate (212139-24-7) → 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-1-propanimidoylpyrrolidin-3-yloxy]phenyl}propanoic acid dihydrochloride

Guidance literature:

ethyl propanimidate hydrochloride; ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate; With triethylamine; In ethanol; at 20 ℃; for 16h;

With hydrogenchloride; for 0.5h; Heating;

DOI:10.1016/j.bmc.2004.02.032

Reference yield: 57.0%

ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate (212139-24-7) + ethyl butyrimidate (998-97-0) → 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-1-butanimidoylpyrrolidin-3-yloxy]phenyl}propanoic acid dihydrochloride

Guidance literature:

ethyl 3-(7-amidino-2-naphthyl)-2-{4-[(3S)-pyrrolidin-3-yloxy]phenyl}propanoate; ethyl butyrimidate; With triethylamine; In ethanol; at 20 ℃; for 16h;

With hydrogenchloride; for 0.5h; Heating;

DOI:10.1016/j.bmc.2004.02.032

upstream raw materials:

2-[4-[[(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy]phenyl]-3-(7-cyano-2-naphthyl)propionic acid ethyl ester