((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

Base Information

Chemical Name:((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester
CAS No.:145929-87-9
Molecular Formula:C₄₅H₅₇ClN₂O₉Si
Molecular Weight:833.494
Hs Code.:

((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

Synonyms:((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

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Chemical Property of ((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

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Technology Process of ((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

There total 14 articles about ((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1738-68-7
Gly-OBz

: 145929-86-8
(2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionic acid

: 145929-87-9
((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1039/c39920001693

Reference yield:

: 621-59-0
isovanillin

: 145929-87-9
((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 63 percent / CuO, K₂CO₃, pyridine / 12 h / Heating

2: 80 percent / Cl₂, SnCl₄ / CH₂Cl₂ / Ambient temperature

3: NaBH₄ / ethanol / 0 °C

4: imidazole / dimethylformamide / Ambient temperature

5: LiAlH₄ / tetrahydrofuran / 0 °C

6: MnO₂ / benzene / Heating

7: 83 percent / diethyl ether / -78 - 0 °C

8: NaN₃ / dimethylformamide / Ambient temperature

9: 240 h / Ambient temperature; pH 4

10: 82 percent / H₂ / 10percent Pd/C / ethyl acetate

11: 100 percent / LiOH, H₂O / tetrahydrofuran

12: 96 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-hydroxybenzotriazole / CH₂Cl₂ / Ambient temperature

With pyridine; 1H-imidazole; manganese(IV) oxide; lithium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; water; hydrogen; chlorine; tin(IV) chloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; copper(II) oxide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39920001693

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 145929-87-9
((2R,3R)-2-tert-Butoxycarbonylamino-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionylamino)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 63 percent / CuO, K₂CO₃, pyridine / 12 h / Heating

2: 80 percent / Cl₂, SnCl₄ / CH₂Cl₂ / Ambient temperature

3: NaBH₄ / ethanol / 0 °C

4: imidazole / dimethylformamide / Ambient temperature

5: LiAlH₄ / tetrahydrofuran / 0 °C

6: MnO₂ / benzene / Heating

7: 83 percent / diethyl ether / -78 - 0 °C

8: NaN₃ / dimethylformamide / Ambient temperature

9: 240 h / Ambient temperature; pH 4

10: 82 percent / H₂ / 10percent Pd/C / ethyl acetate

11: 100 percent / LiOH, H₂O / tetrahydrofuran

12: 96 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-hydroxybenzotriazole / CH₂Cl₂ / Ambient temperature

With pyridine; 1H-imidazole; manganese(IV) oxide; lithium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; water; hydrogen; chlorine; tin(IV) chloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; copper(II) oxide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39920001693