1-benzyl-3-tert-butoxycarbonylaminooxindole

Base Information

• Chemical Name: 1-benzyl-3-tert-butoxycarbonylaminooxindole
• CAS No.: 1620145-28-9
• Molecular Formula: C₂₀H₂₂N₂O₃
• Molecular Weight: 338.406
• Mol file: 1620145-28-9.mol

Synonyms:1-benzyl-3-tert-butoxycarbonylaminooxindole

Chemical Property of 1-benzyl-3-tert-butoxycarbonylaminooxindole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-benzyl-3-tert-butoxycarbonylaminooxindole

There total 1 articles about 1-benzyl-3-tert-butoxycarbonylaminooxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-3-(hydroxyimino)indolin-2-one (28150-91-6) + di-tert-butyl dicarbonate (24424-99-5) → 1-benzyl-3-tert-butoxycarbonylaminooxindole (1620145-28-9)

Guidance literature:

1-benzyl-3-(hydroxyimino)indolin-2-one; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 10h;

di-tert-butyl dicarbonate; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2021.132163

Reference yield: 97.0%

methyl 2-{[(tert-butoxycarbonyl)oxy](phenyl)methyl}acrylate (956833-12-8) + 1-benzyl-3-tert-butoxycarbonylaminooxindole (1620145-28-9) → C25H20N2O2

Guidance literature:

methyl 2-{[(tert-butoxycarbonyl)oxy](phenyl)methyl}acrylate; 1-benzyl-3-tert-butoxycarbonylaminooxindole; With 4-(3-ethyl-4-oxa-1-azatricyclo[4,4,0,0(3,8)]dec-5-yl)quinolin-6-ol; In Hexafluorobenzene; at 20 ℃; for 12h;

With water; toluene-4-sulfonic acid; In Hexafluorobenzene; at 50 ℃; for 5h; Solvent; Reagent/catalyst; enantioselective reaction;

DOI:10.1016/j.tet.2021.132163

Reference yield: 95.0%

C20H22O5 (1316312-88-5) + 1-benzyl-3-tert-butoxycarbonylaminooxindole (1620145-28-9) → C29H22N2O2

Guidance literature:

C₂₀H₂₂O₅; 1-benzyl-3-tert-butoxycarbonylaminooxindole; With 4-(3-ethyl-4-oxa-1-azatricyclo[4,4,0,0(3,8)]dec-5-yl)quinolin-6-ol; In Hexafluorobenzene; at 20 ℃; for 24h;

With water; toluene-4-sulfonic acid; In Hexafluorobenzene; at 50 ℃; for 7h; enantioselective reaction;

DOI:10.1016/j.tet.2021.132163

upstream raw materials:

1-benzyl-3-(hydroxyimino)indolin-2-one

di-tert-butyl dicarbonate