tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate

Base Information

Chemical Name:tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate
CAS No.:147983-31-1
Molecular Formula:C₂₈H₃₉Cl₃N₂O₇
Molecular Weight:621.986
Hs Code.:

Synonyms:tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate

There total 8 articles about tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145588-98-3
(4S)-4-isopropyl-3-(1-oxoheptyl)-2-oxazolidinone

: 147983-31-1
tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) 0.59M LDA / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 5.5 h

2: 1.) 1.65M BuLi / 1.) THF, hexane, 0 deg C, 20 min, 2.) THF, hexane, 1 h

3: 838 mg / 4N HCl / dioxane / Ambient temperature

4: oxalyl chloride / benzene / 2 h / 60 °C

5: pyridine / tetrahydrofuran / 1.5 h / -15 °C

6: H₂ / 10percent Pd/C / methanol / 2 h / Ambient temperature

7: oxalyl chloride / benzene / 2 h / 50 °C

8: N-ethylmorpholine / tetrahydrofuran / 1.) -15 deg C to r.t., 2.) r.t., overnight

With N-ethylmorpholine;; pyridine; hydrogenchloride; n-butyllithium; oxalyl dichloride; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; benzene;
DOI:10.7164/antibiotics.47.1481

Reference yield:

: 147961-55-5
(4S)-4-isopropyl-3-<(2R)-2-(tert-butyloxycarbonylmethyl)-1-oxoheptyl>-2-oxazolidinone

: 147983-31-1
tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 1.65M BuLi / 1.) THF, hexane, 0 deg C, 20 min, 2.) THF, hexane, 1 h

2: 838 mg / 4N HCl / dioxane / Ambient temperature

3: oxalyl chloride / benzene / 2 h / 60 °C

4: pyridine / tetrahydrofuran / 1.5 h / -15 °C

5: H₂ / 10percent Pd/C / methanol / 2 h / Ambient temperature

6: oxalyl chloride / benzene / 2 h / 50 °C

7: N-ethylmorpholine / tetrahydrofuran / 1.) -15 deg C to r.t., 2.) r.t., overnight

With N-ethylmorpholine;; pyridine; hydrogenchloride; n-butyllithium; oxalyl dichloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; benzene;
DOI:10.7164/antibiotics.47.1481

Reference yield:

: (3R)-3-benzyloxycarbonyloctanoyl chloride

: 147983-31-1
tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>heptyl>hexahydropyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / tetrahydrofuran / 1.5 h / -15 °C

2: H₂ / 10percent Pd/C / methanol / 2 h / Ambient temperature

3: oxalyl chloride / benzene / 2 h / 50 °C

4: N-ethylmorpholine / tetrahydrofuran / 1.) -15 deg C to r.t., 2.) r.t., overnight

With N-ethylmorpholine;; pyridine; oxalyl dichloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; benzene;
DOI:10.7164/antibiotics.47.1481