(S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide

Base Information

Chemical Name:(S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide
CAS No.:1341212-03-0
Molecular Formula:C₃₇H₄₄N₃OPS
Molecular Weight:609.816
Hs Code.:

Synonyms:(S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide

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Chemical Property of (S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide

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Technology Process of (S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide

There total 5 articles about (S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1341212-18-7
C₂₀H₂₂N₂OS

: 146476-37-1,1400149-69-0
(2S)-1-(diphenylphosphino)-3-methylbutan-2-amine

: 1341212-03-0
(S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide

Guidance literature:: In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1039/c1ob05881a

Reference yield:

: 100-46-9
benzylamine

: 1341212-03-0
(S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: hydrogenchloride / 1,4-dioxane

3: sodium hydrogencarbonate / dichloromethane / 0 - 20 °C

4: dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1039/c1ob05881a

Reference yield:

: 1048692-42-7
(S)-tert-butyl (1-(dibenzylamino)-3-methyl-1-oxobutan-2-yl)carbamate

: 1341212-03-0
(S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane

2: sodium hydrogencarbonate / dichloromethane / 0 - 20 °C

3: dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane;
DOI:10.1039/c1ob05881a