β-thiophenylacrolein

Base Information

• Chemical Name: β-thiophenylacrolein
• CAS No.: 80227-71-0
• Molecular Formula: C₉H₈OS
• Molecular Weight: 164.228
• Mol file: 80227-71-0.mol

Synonyms:β-thiophenylacrolein

Chemical Property of β-thiophenylacrolein

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-thiophenylacrolein

There total 9 articles about β-thiophenylacrolein which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(Phenylthio)propenenitrile (90322-80-8) → β-thiophenylacrolein (80227-71-0)

Guidance literature:

With diisobutylaluminium hydride; In toluene; for 24h; Ambient temperature;

DOI:10.1039/p19960001905

Reference yield: 40.0%

1-((E)-3-Ethoxy-1-phenylsulfanyl-allyl)-1H-benzotriazole → β-thiophenylacrolein (80227-71-0)

Guidance literature:

With water; zinc dibromide; In tetrahydrofuran; for 0.5h; Heating;

DOI:10.1055/s-1995-4102

Reference yield:

3-(phenylthio)prop-2-en-1-ol (15286-68-7) → (Z)-3-(phenylthio)-2-propenal (80227-70-9) + β-thiophenylacrolein (80227-71-0)

Guidance literature:

With tert.-butylhydroperoxide; dimesityl diselenide; In benzene; for 0.75h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00344a017

upstream raw materials:

3-phenylsulfanyl-propionaldehyde

3-(phenylthio)prop-2-en-1-ol

thiophenol

acrolein

Downstream raw materials:

(E)-6-Phenylsulfanyl-hex-5-ene-1,4-diol

6-methyl-2-thiophenyl-1,4-naphthoquinone

5-Methyl-2-phenyl-3-phenylsulfanyl-furan

[(E)-3-Phenylsulfanyl-prop-2-en-(E)-ylidene]-trimethylsilanyl-amine

Refernces

• 1、 Katritzky,Wu,Xie,Rachwal,Rachwal,Jiang,Zhang,Lang. "The origins of the benzotriazole project, its versatility illustrated by a new --C = CHCH+OEt synthon, and novel syntheses of α,β-unsaturated aldehydes and ketones, furans, pyrroles and allyl ethers". . p. 1315 - 1323. Retrieved 2007/10/02.
• 2、 Batty, Duncan,Crich, David,Fortt, Simon M.. "Acyl Radical Cyclizations in Synthesis. Part 3. Synthesis of (+/-)-trans-3,5-Bis(t-butyldimethylsiloxy)-2-Methylenecyclohexanone, an 'A' Ring Model for 1α,25-Dihydroxyvitamin D3". . p. 2875 - 2879. Retrieved 2007/10/02.