(4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone

Base Information

Chemical Name:(4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone
CAS No.:1364523-79-4
Molecular Formula:C₂₂H₂₂Cl₂N₄O₃
Molecular Weight:461.348
Hs Code.:

Synonyms:(4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone

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Chemical Property of (4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone

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Technology Process of (4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone

There total 5 articles about (4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2,4-dichloro-5-(piperazin-1-yl)aniline ditrifluoroacetate

: 93041-44-2
3-(2-methoxyphenyl)-5-methylisoxazole-4-carboxylic acid

: 1364523-79-4
(4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 823-54-1
3-bromo-4-chloroaniline

: 1364523-79-4
(4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 20 °C

2.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 110 °C

3.1: N-chloro-succinimide; trifluoroacetic acid / dichloromethane; methanol / -40 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; N-chloro-succinimide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium diacetate; In methanol; dichloromethane; toluene;

Reference yield:

: 1080573-26-7
tert-butyl N-(3-bromo-4-chloro-phenyl)carbamate

: 1364523-79-4
(4-(5-amino-2,4-dichlorophenyl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 110 °C

2: N-chloro-succinimide; trifluoroacetic acid / dichloromethane; methanol / -40 - 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; N-chloro-succinimide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium diacetate; In methanol; dichloromethane; toluene;