N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone

Base Information

Chemical Name:N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone
CAS No.:301152-33-0
Molecular Formula:C₂₈H₂₈N₆O₄
Molecular Weight:512.568
Hs Code.:

Synonyms:N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone

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Technology Process of N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone

There total 3 articles about N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 14210-25-4
5-Chloro-1-phenyltetrazole

: 68729-75-9
N-cyclopropylmethyl-14-formamidomorphinone

: 301152-33-0
N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 22h;
DOI:10.1021/jm0009641

Reference yield:

: 180415-87-6
14β-amino-7,8-dihydro-17-cyclopropylmethylnorcodeinone

: 301152-33-0
N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / Ac₂O / 4 h

2: 76 percent / BBr₃ / CH₂Cl₂ / 4 h / -30 °C

3: 73 percent / K₂CO₃ / dimethylformamide / 22 h / 20 °C

With acetic anhydride; boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: demethylation / 3: Substitution;
DOI:10.1021/jm0009641

Reference yield:

: 68729-76-0
N-cyclopropylmethyl-14-formamidocodeinone

: 301152-33-0
N-cyclopropylmethyl-14-formamido-3-(1-phenyl-1H-5-tetrazolyl)morphinone

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / BBr₃ / CH₂Cl₂ / 4 h / -30 °C

2: 73 percent / K₂CO₃ / dimethylformamide / 22 h / 20 °C

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: demethylation / 2: Substitution;
DOI:10.1021/jm0009641