[1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester

Base Information

• Chemical Name: [1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester
• CAS No.: 524018-29-9
• Molecular Formula: C₃₀H₃₁FN₂O₃
• Molecular Weight: 486.586
• Mol file: 524018-29-9.mol

Synonyms:[1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester

Chemical Property of [1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester

There total 5 articles about [1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diethyl 1-cyanomethylphosphonate (2537-48-6) + [2-(4-fluoro-phenyl)-1-(5-naphthalen-2-yl-4-oxo-tetrahydro-pyran-2-yl)-ethyl]carbamic acid tert-butyl ester (524018-19-7) → [1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester (524018-29-9)

Guidance literature:

diethyl 1-cyanomethylphosphonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

[2-(4-fluoro-phenyl)-1-(5-naphthalen-2-yl-4-oxo-tetrahydro-pyran-2-yl)-ethyl]carbamic acid tert-butyl ester; In tetrahydrofuran; at -40 ℃; for 3h;

DOI:10.1021/ol027281v

Reference yield:

naphthalene-2-boronic acid (32316-92-0) → [1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester (524018-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 61 percent / Na₂CO₃ / tetrakis triphenylphosphinepalladium / benzene; H₂O / 3 h / Heating

2.1: 83 percent / L-Selecrtide / tetrahydrofuran / 0.5 h / -78 °C

3.1: NaH / tetrahydrofuran / 1 h / 0 °C

3.2: 90 percent / tetrahydrofuran / 3 h / -40 °C

With L-Selectride; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; benzene; 1.1: Suzuki coupling / 3.2: Horner-Emmons reaction;

DOI:10.1021/ol027281v

Reference yield:

[1-(4-oxo-3,4-dihydro-2H-pyran-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester (524018-08-4) → [1-(4-cyanomethylene-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester (524018-29-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 70 percent / Br₂; Et₃N / CCl₄ / 1 h / 20 °C

2.1: 61 percent / Na₂CO₃ / tetrakis triphenylphosphinepalladium / benzene; H₂O / 3 h / Heating

3.1: 83 percent / L-Selecrtide / tetrahydrofuran / 0.5 h / -78 °C

4.1: NaH / tetrahydrofuran / 1 h / 0 °C

4.2: 90 percent / tetrahydrofuran / 3 h / -40 °C

With bromine; L-Selectride; sodium hydride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; water; benzene; 2.1: Suzuki coupling / 4.2: Horner-Emmons reaction;

DOI:10.1021/ol027281v

upstream raw materials:

diethyl 1-cyanomethylphosphonate

[2-(4-fluoro-phenyl)-1-(5-naphthalen-2-yl-4-oxo-tetrahydro-pyran-2-yl)-ethyl]carbamic acid tert-butyl ester

naphthalene-2-boronic acid

[1-(4-oxo-3,4-dihydro-2H-pyran-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Downstream raw materials:

C₄₁H₅₅FN₄O₇

C₄₁H₅₅FN₄O₇

[1-(4-cyanomethyl-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester

[1-(4-cyanomethyl-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester