Isoquinoline, 7-fluoro-3,4-dihydro-1-methyl- (9CI)

Base Information

• Chemical Name: Isoquinoline, 7-fluoro-3,4-dihydro-1-methyl- (9CI)
• CAS No.: 269402-41-7
• Molecular Formula: C₁₀H₁₀FN
• Molecular Weight: 163.195
• Mol file: 269402-41-7.mol

Synonyms:7-Fluoro-1-methyl-3,4-dihydroisoquinoline

Chemical Property of Isoquinoline, 7-fluoro-3,4-dihydro-1-methyl- (9CI)

Chemical Property:

• PSA: 12.36000
• LogP: 1.62640

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoquinoline, 7-fluoro-3,4-dihydro-1-methyl- (9CI)

There total 3 articles about Isoquinoline, 7-fluoro-3,4-dihydro-1-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(4-fluorophenyl)ethyl]acetamide → 7-fluoro-1-methyl-3,4-dihydroisoquinoline (269402-41-7)

Guidance literature:

N-[2-(4-fluorophenyl)ethyl]acetamide; With oxalyl dichloride; In dichloromethane; at 10 - 20 ℃;

With iron(III) chloride; In dichloromethane; at 20 ℃; for 16h;

With sulfuric acid; In methanol; at 0 ℃; for 16h; Reflux;

Reference yield:

4-fluoro-2-phenethylamine (1583-88-6) → 7-fluoro-1-methyl-3,4-dihydroisoquinoline (269402-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 72 h / 0 - 20 °C

2.1: oxalyl dichloride / dichloromethane / 10 - 20 °C

2.2: 16 h / 20 °C

2.3: 16 h / 0 °C / Reflux

With oxalyl dichloride; triethylamine; In dichloromethane;

Reference yield:

→ 7-fluoro-1-methyl-3,4-dihydroisoquinoline (269402-41-7)

Guidance literature:

upstream raw materials:

4-fluoro-2-phenethylamine

Refernces

• 1、 -. "Pyrimidine derivatives and processes for the preparation thereof". . . Retrieved 2008/06/13.